More than 110,000 Norfolk and Waveney households eligible for means-tested benefits will receive the first of their £900 cost-of-living payments from the spring.
And a further 110,000 people on disability benefits will get a separate £150 payment this summer amid the cost-of-living crisis.
Benefits which could make claimants eligible for the £301 payment include Universal Credit, tax credits, Jobseekers Allowance and Income Support.
Eligible individuals do not need to apply for payments, as they are made automatically.
The estimated number of households for the means-tested payment are Breckland (13,900), Broadland (10,100), Great Yarmouth (16,300) West Norfolk (16,600) North Norfolk (10,600), Norwich (19,300), South Norfolk (11,300) and East Suffolk (25,500).
Further payments will be made this autumn and next spring.
Disability payments will be made to an estimated 118,700 people in Norfolk and East Suffolk.
Chancellor Jeremy Hunt said: "These payments are the next part of the significant support we are providing through this challenging time, with millions of vulnerable households receiving £900 directly into their bank accounts this financial year alongside additional help for pensioners and those with disabilities."
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