Andy Murray let frustration get the better of him as he crashed out of the US Open after losing a five-set thriller to Kei Nishikori.

Eastern Daily Press: Kei Nishikori, of Japan, reacts after winning a point against Andy Murray, of the United Kingdom, during the quarterfinals of the U.S. Open tennis tournament, Wednesday, Sept. 7, 2016, in New York. (AP Photo/Julio Cortez)Kei Nishikori, of Japan, reacts after winning a point against Andy Murray, of the United Kingdom, during the quarterfinals of the U.S. Open tennis tournament, Wednesday, Sept. 7, 2016, in New York. (AP Photo/Julio Cortez) (Image: Copyright 2016 The Associated Press. All rights reserved.)

Murray had been in complete control in Arthur Ashe Stadium until first a rain delay and then, most crucially, a loud noise on break point derailed the 29-year-old's charge.

Croatian umpire Marija Cicak ordered the point to be replayed and a fuming Murray lost the next seven games in a row as Nishikori claimed a shock 1-6 6-4 4-6 6-1 7-5 victory.

Nishikori, speaking on court, said: 'It was too exciting on the court, but I tried to stay calm. In the beginning I didn't start well, he has a great return, but I finished well.

'The rain delay helped me to change tactics. I tried to hit a few more drop-shots than usual today and it worked really well today.

'I have great memories of this place and this is a great chance for me in the semi-finals.'

The Japanese will now face either Juan Martin del Potro or Stan Wawrinka for a place in Sunday's final.

Elsewhere Murray's older brother, Jamie, and Bruno Soares are two wins away from a second grand slam title after the doubles pair advanced to the semi-finals of the US Open.

Murray and Soares edged out Australia's Chris Guccione and Brazilian Andre Sa 7-6 (11/9) 2-6 6-3 at Flushing Meadows.

The fourth seeds will now face either French duo Nicolas Mahut and Pierre-Hugues Herbert or Sweden's Robert Lindstedt and Aisam-ul-Haq Qureshi of Pakistan in the last four.

After clinching their first major title at the Australian Open in January, Murray and Soares are now chasing a repeat on the hard courts in New York.

They reached the quarter-finals at Wimbledon together this summer and have secured spots at the ATP World Tour Finals after winning here in the third round.

The first set was the tightest on Court 17, drifting into a tie-break as neither pair managed a break of serve.

Murray and Soares held their nerve, however, and grabbed the set at 10-9 when Guccione dumped a backhand volley into the net.

Guccione and Sa fought back in the second, breaking twice to draw level, but Guccione failed to hold in the decider as Murray and Soares closed out a hard-fought victory.