The A140 between Norwich and Aylsham was closed because of a three-vehicle crash near Horsham St Faith, with motorists urged to avoid the area.
Police,firefighters and the ambulance service were called to the crash, at the turning to Horsham St Faith, to the north of Norwich, just before 10am.
Three cars were involved in the crash.
Police tweeted that the road had been closed while emergency services dealt with the crash.
They asked drivers to avoid the area.
Three ambulances and the East of England Ambulance Service duty ambulance officer went to the scene.
A spokesman for the East of England Ambulance Service Trust, said: 'Six people were assessed at the scene and two people were taken to the Norfolk and Norwich University Hospital with minor injuries.'
Fire crews from Earlham and Sprowston attended and helped to make the scene safe.
The road had re-opened by 12pm.
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