A stretch of the A47 was closed for four hours after a serious fail-to-stop crash at North Burlingham.
Emergency services were called to the A47 just before 3.15pm on Sunday afternoon, when a small silver Nissan collided with a black Citroen, causing the drivers of the Citroen to be thrown from the car.
The Nissan did not stop at the scene.
The East of England Ambulance Service treated a man who had suffered a head injury and a second patient with a back injury. Both were taken to the Norfolk and Norwich University Hospital for further treatment.
Fire crews from Acle, Carrow and Sprowston attended, making the vehicles, both of which were heading towards Great Yarmouth, safe.
The road was closed eastbound between the Cucumber Lane roundabout at Brundall and the Acle roundabout in Acle while vehicles were recovered and accident investigation work began.
The busy route reopened at about 7.30pm.
• Police are keen to hear from anyone with information. Contact 101.
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