Emergency services were called to a rush hour crash on the Acle Straight.
The police and ambulance service were called at about 5.20pm.
Firefighters from Great Yarmouth and Gorleston also went to the scene and helped to get casualties from their vehicles following the crash.
Queues snaked back to Great Yarmouth. First buses tweeted that services X1 and X11 were being disrupted because of the crash and delays were expected throughout the evening.
The road had reopened by 7.45pm.
Comments: Our rules
We want our comments to be a lively and valuable part of our community - a place where readers can debate and engage with the most important local issues. The ability to comment on our stories is a privilege, not a right, however, and that privilege may be withdrawn if it is abused or misused.
Please report any comments that break our rules.
Read the rules here