Despite gargantuan advances in medical science, we still don't fully understand the complexities of the human brain: its ability to process vast quantities of information, solve problems and store memories at speeds that put supercomputers to shame.

Eastern Daily Press: Film pix 23/7/15Film pix 23/7/15 (Image: Archant)

Pixar Animation Studios, the wizards who conjured the Toy Story trilogy, contemplate the vagaries of neuropsychology with this visually stunning and emotionally rich comedy, which unfolds predominantly inside the head of a little girl.

This high-brow concept doesn't seem like the most accessible subject matter for a family-oriented computer animation.

But directors Pete Docter and Ronaldo Del Carmen elegantly tilt their film at the windmills of the mind and deliver a hilarious, heartfelt and ultimately life-affirming adventure that celebrates childhood innocence, family unity and the power of the human spirit to overcome adversity.

Laughter and tears abound, as well as cute visual gags, ensuring parents will be repeatedly dabbing their eyes while children whoop and gurgle with glee at the slapstick and rollicking action sequences.

A mother (voiced by Diane Lane) and father (Kyle MacLachlan) welcome a baby girl called Riley (Kaitlyn Dias) into the world.

From the moment she opens her eyes, Riley's mood is shaped by five coloured emotions - golden Joy (Amy Poehler), blue Sadness (Phyllis Smith), purple Fear (Bill Hader), red Anger (Lewis Black) and green Disgust (Mindy Kaling) - which bicker behind a large control desk laden with buttons and levers.

Joy is the dominant emotion in Headquarters and she safeguards Riley's memories, which are stored as glowing orbs, tinged with the colour of the emotion that prevailed at the time.

When Riley turns 11, her parents relocate from Minnesota to San Francisco.

Traumatic events such as a first day at a new school nudge Sadness to the fore.

Following an altercation, sworn rivals Joy and Sadness are expelled from Headquarters and find themselves stranded in the labyrinth of Riley's long-term memories.

Aided by Riley's imaginary friend Bing Bong (Richard Kind), Joy and Sadness blaze a haphazard trail on the chugging train of thought back to Fear, Anger and Disgust, who have been left in charge of Headquarters, with disastrous consequences.

Inside Out is Pixar's best film since the holy animated trilogy of WALL-E, Up and Toy Story 3.

Docter's script, co-written by Meg LeFauve and Josh Cooley, glisters with imagination, wit and invention, delivering guffaws with detours into the heads of Riley's parents as they attempt to deal with her pre-teenage rebellion.

Vocal performances are note perfect, led by Poehler's exuberant portrayal of Joy and Smith's sincere embodiment of Sadness, who tugs heartstrings as the film reaches its exquisite conclusion.

The film is preceded by a short: a musical love story entitled Lava between two volcanoes called Uku and Lele, directed by James Ford Murphy.

Joy and Sadness shared blissful control of my mind throughout.

***** (5 stars)