Firefighters battled to free two people after a crash between a truck and a car, which saw a man airlifted to hospital.
Emergency services, including the air ambulance, were called to the crash at Little Ryburgh, near Fakenham, at 6.30pm last night.
The crash, involving a black Volkswagen Golf and what police described as a scaffolding lorry, happened on the A1067 at The Street.
Fire crews from Fakenham, one from Dereham and the heavy rescue pump from Carrow all went to the scene, along with three ambulance crews, two rapid response vehicles and two ambulance officers.
The firefighters had to use hydraulic rescue equipment to free two people from one of the vehicles.
A spokesman for the East of England Ambulance Service NHS Trust said a man, believed to be in his 20s had been airlifted to the Norfolk and Norwich University Hospital by the East Anglian Air Ambulance.
He said a patient with a suspected broken wrist had been taken to the Queen Elizabeth Hospital at King's Lynn by ambulance, while a third patient, with chest pains, had been taken to the Norfolk and Norwich University Hospital by ambulance.
The A1067 was closed to traffic in both directions while emergency services worked to rescue the casualties, make the scene safe and then investigate the circumstances surrounding the crash.
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