The main road from Wrentham to Southwold in Suffolk is impassable due to a jackknifed lorry trailer at South Cove.
Recovery along the B1127 is unable to start until Thursday morning.
Suffolk Police said Highways had been contacted to signpost a diversion.
'But with their current deployments due to the weather this may take some time,' said a spokesperson.
'Police are urging people to find a different route and avoid the area.'
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