An air ambulance was called to assist with a crash involving a motorcycle on the B1077 in Winfarthing, near Diss.
Norfolk Police closed Mile Road for more than an hour near to its junction with Heath Road following the accident.
Emergency services were called at just after 8.30pm on Tuesday to reports that a motorbike had left the road.
The spokesman said the road had now reopened.
Norfolk fire service sent crews from Attleborough and Diss to the scene.
Two ambulances, a rapid response vehicle and the East Anglian Air Ambulance attended and treated two patients.
Both were taken to Norfolk and Norwich University Hospital for further care.
Their injuries are not believed to be life threatening.
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