The event, a Taste of Norfolk, is being hosted by The Marquess and Marchioness of Cholmondeley at Houghton Hall, near Fakenham, on Wednesday night.
All guests have been invited as a special thank you for supporting the charity's £10m nook appeal.
EACH chief executive Graham Butland: 'A Taste of Norfolk is a truly unprecedented event for EACH and has only been made possible following many months of hard work and dedication from our voluntary committee, led by our Patron Emma Deterding and Philippa Pease of Purple Chilli Events.
'We want to say a huge thank you to Emma and all the committee members who have worked so tirelessly, and to the many companies and individuals who have so generously shown their support.'
A special five course meal will be served with courses created and cooked by five world renowned chefs - Norfolk's Galton Blackiston, Sat Bains, Claude Bosi, Tom Kerridge and Mark Edwards.
The evening will also feature a number of exclusive highlights for guests, beginning with a champagne reception featuring musical entertainment by the Jefford Brothers and Sam Aldersey-Williams and magician Archie Manners.
The EACH Treehouse Choir will be performing after dinner followed by a speech from parent Charlotte Markham. Charlotte and her family received care and support from EACH in Ipswich when her son Elliot died at just a few hours old.
The dinner will be brought to a close with speeches from critically acclaimed author and EACH Ambassador Anthony Horowitz OBE and the Marquess of Cholmondeley.
Anthony has been an Ambassador of EACH since 2008 and is passionate about the work of the charity. He recently visited the existing hospice in Quidenham to find out more about the plans for the nook and why a new building in Norfolk is so important for care delivery.
EACH Patron and event organiser Emma Deterding said: 'Having been a Patron of EACH for over 25 years, I am proud to be part of something so inspirational.
'I continue to be amazed by how hard EACH works to ensure that hundreds of children with life-threatening conditions and their families in East Anglia get the best care possible.'
'I would like to thank Their Royal Highnesses The Duke and Duchess of Cambridge for agreeing to join us for this amazing evening. Special thanks are also due to The Marquess and Marchioness of Cholmondeley for so generously offering us Houghton Hall as a venue.
'There have been so many companies and individuals who have generously and graciously shown their support. We are so grateful.'
EACH provides vital services caring for children and young people with life-threatening conditions across East Anglia and supporting their families.
It has outgrown its current hospice in Quidenham, due to demand and the changing and more complex needs of the children and young people they care for.
The nook appeal is the charity's campaign to raise £10 million to transform children's palliative care across Norfolk, including building a new hospice called the nook.
It will be built on a five-acre woodland site in Framingham Earl just south of Norwich and will offer services which are either currently unavailable or extremely limited at Quidenham hospice such as a hydrotherapy pool, music studio, large rooms for on-site family support groups, larger and more accessible outside space for children to explore and play and private rooms for one-to-one counselling.
Emma Deterding said: 'The nook is now one step closer and we are incredibly grateful to all our guests for donating significant money towards the building of the new hospice. We want everyone to spread the word about the amazing work of EACH and desperately need the nook to become a reality as soon as possible.'
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